Section of Experimental Pathology and Oncology
The Section of Experimental Pathology and Oncology utilizes in vitro methods at the cellular and molecular level as well as in vivo approaches to investigate oncological, inflammatory and degenerative human pathologies. Research projects include: the role of proteases and of their receptors in tumor proliferation, invasion and metastasis, and in rheumatic diseases; tumor microenvironment; metabolic heterogeneity of tumor cells, metabolic regulation of tumor progression, stem cell properties and drug resistance; new nanocarrier delivery systems of anti-cancer drugs and nanomedicine-based theranostics of tumors; the role of growth factors, tyrosine kinase receptors and mitogen-activated protein kinases in cancer (breast and gastric carcinomas, melanomas) chemoresistance and in the design of molecularly-targeted therapies; post-transcriptional control of gene expression, gene editing and apoptosis deregulation in normal and cancer cells; role of glicomics, metabolomics, gut microbioma, gene expression and DNA methylation in immunosenescence and inflammaging; nutraceutical approaches and polyphenol treatment to target cell senescence, Alzheimer disease and tumor progression.
Aging, longevity and age-related diseases (Coordinator Daniela Monti)
Post transcriptional regulation in cancer (Coordinator Nicola Schiavone)
Molecular Oncology & Cell Signalling (Coordinator: Elisabetta Rovida)
Laboratorio di Medicina Traslazionale (Translational Research Laboratory)
Ultimo aggiornamento
16.01.2024