Ricerca Gruppi di ricerca e contributi alla ricercaSection of Clinical DiagnosticsGruppo Petraglia

Gruppo Petraglia

 

Coordinator of Research Team

Name: FELICE PETRAGLIA

Position: PROFESSOR

Name of Research Team: WOMEN’S HEALTH

e-mail: felice-petraglia@unifi.it

telephone number: 055 7949844 
 

Brief biographical sketch of the Coordinator

Personal Data:

Date and place of birth: 15/11/1956, Italy

 

Education:

1980      Doctor of Medicine, University of Siena, Siena, Italy

1984      Specialist in Obstetrics and Gynecology

1987      Specialist in Endocrinology.

1998– 1992        Fellow at Obstetrics and Gynecology, University of Modena, Italy

1992– 1997        Associate Professor Obstetrics and Gynecology, University of Modena, Italy 

1995– 1996        Associate Professor Obstetrics and Gynecology, University of Pisa, Italy

1997- 2000         Professor of Obstetrics and Gynecology University of Udine, Italy.

2000– 2017        Professor of Obstetrics and Gynecology University of Siena, Italy             

2017 -                   Professor of Obstetrics and Gynecology University of Florence, Italy      

 

Academic and Professional Appointments:

ACADEMIC APPOINTMENTS

2002-2008           Chair of the Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

2008- today       Interuniversity Research Center for Reproduction Diseases (CIRMAR)

 

HOSPITAL AFFILIATION

1988-1992           Director Menopause Center, University of Modena, Modena, Italy

1992-1995           Attending Staff, Obstetrics and Gynecology, University of Modena, Modena, Italy

1997-2000           Chair Division in Obstetrics and Gynecology, University of Udine, Udine, Italy

2007-2010           Chair Department of Maternity and Infancy, University of Siena, Siena, Italy

2000-2017           Chair Division in Obstetrics and Gynecology, University of Siena, Siena, Italy

2017-today        Chair Division in Obstetrics and Gynecology, Careggi University Hospital, Florence, Italy

 

NATIONAL and INTERNATIONAL APPOINTMENTS

-              Medical Research Council of Canada

-              Australian Medical Research Council

-              Royal College of Obstetricians and Gynecologists

-              Wellcome Trust

-              Swiss National Science Foundation

-              Research Grants Council Hong Kong

-              United States-Israel Binational Science Foundation

-              Italian Ministry of University and Research (MIUR)

-              Italian Ministry of Health

                Italian Drug Agency (AIFA) as National expert of Obstetrics and Gynecology (2011-2013)

 

GRANT AWARDS                                                                         

1989-1992           Italian National Research Council (CNR): ”Role of inhibin and activin in human pregnancy”

1993-1998           Italian National Research Council (CNR): “Mechanisms of onset of labor”

2000-2001            Italian Ministry University (MIUR): “Gestational liver diseases: role of activin/inhibin/ follistatin”

2002-2003           Italian Ministry University (MIUR): “Identification and role of placental regulatory factors in  maternal – fetal homeostasis”

2002-2004          AIRC Grant for “New markers for trophoblastic tumors”

2006-2007           Italian Ministry University (MIUR): “Placental Biochemical and Biophysical markers for gestational disorders”

2008-2009           Italian Ministry University (MIUR): ”Preterm birth: the obstetric syndrome” 

2010-2013           Italian Ministry University (MIUR): ”Preterm birth: biochemical, biophysical, placental factors in feto-placental unit”

 

PATENTS

1) United States Patent Application Pubblication - Method and System for Fetal Weight Evaluation,

 US 2007/0038093A1

2) European Patent Aplication -Method and System for Foetal Weight Evaluation, EP 1743581A1

3). United States Patent and Trademark Office –for serum markers of prostate cancer, filed in the United States on April 28, 2008 with    deposit number 61/048,412

 

PROFESSIONAL HONORS

1988                      Republic of San Marino Award on Reproductive Medicine

1992                      “C. Pansini” Award of the Italian Society of Obstetrics and Gynaecology

1999                      “PG Chiodini” Award of the Italian Society of Endocrinology

2001                      International Award “Arnaldo Bruno” National Academy of Lincei

2007                     Endocrine Society Award for Excellence in publications in the Journal of Clinical Endocrinology and Metabolism in 2007.

2010                      Fellow ad Eundem of the Royal College of Obstetricians and Gynaecologists (RCOG)

2011                      McIlrath Guest Professorship, Sydney, Australia

2014                      Rogerio A. Lobo Award for the publication on Reproductive Sciences

 

 

Visiting scientist:

1985 - 1987        Visiting Scientist at the Salk Institute, La Jolla, California, USA

1993                      University of Wien, Vienna, Austria

2005-2016            Adjunct Professor Department of Obstetrics and Gynecology, University of Toronto, Canada

2015-2016          Visiting Professor, Obstetrics and Gynecology, Capital University, Beijing, China

 

 

Member of the scientific board of the Doctorate/PhD Program in

2000-2010           Coordinator of PhD program in Gynecology and Obstetrics Medical Biotechnology, University of Siena

2011-2014            Coordinator of PhD program Molecular Medicine (Pegaso), University of Siena

                                               2015-2016         Scientific board of PhD program Molecular Medicine (Pegaso), University of Siena

2001-2016           Coordinator of Resident School of Hormonal therapy in Gynecology and Obstetrics, University of Siena

2018-today         Scientific board of PhD program in Biomedical Sciences, University of Florence

 

 

Member of the following Scientific Societies

PROFESSIONAL SOCIETY COMMITTEE APPOINTMENTS

1990-2012           Executive Committee of International Society Gynecological Endocrinology (ISGE)

1992-1994           Scientific Committee of the Italian Society of Endocrinology

1996-1999           Scientific Committee of the European Association of Gynaecologist and Obstetrician (EAGO)

1997-2007           Executive Committee of the Italian Association Placenta

2001-2007           Executive Committee Italian Association for University Gynecologist (AGUI)

2001-2007           Scientific Committee Italian Society of Reproductive Pathophysiology

2003-2007           Council of the Society for Gynecological Investigation (SGI)

2003-2006           Membership Committee of the Endocrine Society

2004-2007           Deputy of the Special Interest Group on Reproductive Endocrinology of the European Society Human Reproduction Embriology (ESHRE)

2006-2010           Council of European Board and College Obstetrics and Gynecology (EBCOG)

2008-2009           President of the Society for Gynecological Investigation (SGI)

2010-2012           Executive Board of the International Federation of Gynecology and Obstetrics (FIGO)

 

2011-2015           Correspondent Member of the Pontificial Academy for Life. (PAL)

2011-2012           President of the Italian Society for Reproduction

2012-2014           Scientific Board European Endometriosis League

2015-2018           Board of the Society for Endometriosis and Uterine Disorders (SEUD)

2018- today      President of the Society for Endometriosis and Uterine Disorders (SEUD)

 

PROFESSIONAL SOCIETY MEMBERSHIP

-              Society for Reproductive Investigation (SRI)

-              Society of Endometriosis and Uterine Disorders (SEUD)

-              European Society of Human Reproduction and Embriology (ESHRE)

-              Italian Society of Obstetrics and Gynecology (SIGO)

-              Italian Society for Reproduction (SIDR)

 

Member of the editorial board of the following Journals

EDITORIAL EXPERIENCE

Editor- in – Chief:

2013 - today                      Human Reproduction Update

2009-2012                           Journal of Endometriosis

Associate Editor:

2007- 2012                Reproductive Sciences

2004-2007                           Journal of Endocrinological Investigation

2005-2009                           Human Reproduction Update

Editorial Board:

1993-1999           Journal of Endocrinological Investigation

1995-1999           Journal Clinical Endocrinology and Metabolism

1997-2004            European Journal of Endocrinology

1995-1998           Placenta

1999                      References en Gynecologie Obstetrique

2001- 2007         Journal of Society Gynecological Investigation

2000-today         Gynecological Endocrinology

2001                      Prenatal and Neonatal Medicine

2005-today         Faculty Advisory Board of the Faculty of 1000 Medicine website (Section Head in Reproductive Endocrinology)

2007- 2012         Reproductive Biology Insight

2007                      The Open Endocrinology Journal

2007                      Open Endocrinology Review

 

Research Team

1. Mecacci Federico
2. Vannuccini Silvia
3. Rambaldi Marianna
4. Simeone Serena
5. Bucciantini Sandra
6. Pampaloni Francesca
7. Pasquini Lucia
8. Becorpi Angela
9. Piciocchi Luigi
10. Cioni Riccardo
11. Donati Chiara
12. Bernacchioni Caterina
13. Cencetti Francesca

 

 

Current research interests  

 

• • Menstrual disorders:
    • Quality of life in women with irregular period and psychological/psychiatric symptoms
    • Influence of menstrual cycle in quality of life and perceived stress in female young athelts
  • Uterine disorders: endometriosis, adenomyosis, uterine fibroids
    • Basic science
      • Role of estrogen and progesterone receptors encoding genes in uterine disorders (SNPs, epigenetic modification of gene promoters)
      • Role of inflammatory markers, immune system regulation and oxidative stress markers in uterine disorders
    • Clinical studies
      • Quality of life and psychological symptoms in uterine disorders
      • Ultrasound features of adenomyosis and severity of clinical symptoms
      • Ultrasound features of adenomyosis in adolescents with dysmenorrhea
      • Factors related to the first 1000 days of life in women with uterine disorders in adult life.
      • Clinical trials on drugs for uterine fibroids treatment
      • Clinical trials on drugs for endometriosis
  • Gynecological oncology: endometrial and cervical cancer
    • Basic science
      • Genetic profile of endometrial cancer according to recurrence
      • Liquid biopsy (circulating DNA with mutations) in blood of women with endometrial cancer for early diagnosis or follow up
      • Role of urinary HPV (HPV type and levels) in cervical cancer.
  • Pregnancy complications: preterm birth, gestational diabetes, fetal growth restriction
    • Basic science
      • Maternal serum and placental molecular markers of inflammation and oxidative stress in obstetric syndromes
      • Immune system dysfunction in preterm birth
      • Autophagy associated proteins and preterm birth in twin pregnancy
    • Clinical studies
      • Factors related to the first 1000 days of life in pregnant women with obstetric complications.
      • Longitudinal evaluation of fetal growth in gestational diabetes: the role of fetal growth velocity
      • Ultrasound features of myometrium in women with history of postpartum hemorrhage
      • Factors related to insulin vs nutritional therapy in women with gestational diabetes
      • Longitudinal evaluation of vital signs in pregnancy as marker of stress
      • Perceived stress score and postpartum depression risk
  • Menopause
    • • Immunological profile of young women with premature ovarian failure

 

Current / recent sources of funding

                1) Ente Cassa di Risparmio Firenze

 

10 best publications of the last 5 years

1)Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Reis FM, Petraglia F, Taylor RN. Hum Reprod Update.;19(4):406-18,2013

2) Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function. Islam MS, Catherino WH, Protic O, Janjusevic M, Gray PC, Giannubilo SR, Ciavattini A, Lamanna P, Tranquilli AL, Petraglia F, Castellucci M, Ciarmela P. J Clin Endocrinol Metab.;99(5):E775-85;2014

3) Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition. Voltolini C, Battersby S, Novembri R, Torricelli M, Severi FM, Petraglia F, Norman JE. Endocrinology.;156(2):670-679;2015

4) Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management. Abrão MS, Petraglia F, Falcone T, Keckstein J, Osuga Y, Chapron C. Hum Reprod Update.;21(3):329-339;2015

5) Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, Petraglia F. Hum Reprod Update.;22(1):104-15;2016

6) Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions. Gori M, Luddi A, Belmonte G, Piomboni P, Tosti C, Funghi L, Zupi E, Lazzeri L, Petraglia F. Fertil Steril.;105(2):435-43;2016

7) Potential influence of in utero and early neonatal exposures on the later development of endometriosis. Vannuccini S, Lazzeri L, Orlandini C, Tosti C, Clifton VL, Petraglia F. Fertil Steril.;105(4):997-1002;2016

8) Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia. Funghi L, Damiani F, Yen CF, Lee CL, Lombardi A, Schatz F, Lockwood CJ, Marcolongo P, Petraglia F, Arcuri F. Mol Cell Endocrinol.;437:163-170;2016

9) 11β-hydroxysteroid dehydrogenase type 1 and pregnancy: Role in the timing of labour onset and in myometrial contraction. Damiani F, Makieva S, Rinaldi SF, Hua L, Marcolongo P, Petraglia F, Norman JE. Mol Cell Endocrinol. 2017 May 15;447:79-86.

10) Pathogenesis of adenomyosis: an update on molecular mechanisms. Vannuccini S, Tosti C, Carmona F, Huang SJ, Chapron C, Guo SW, Petraglia F. Reprod Biomed Online. 2017 Nov;35(5):592-601.

 

Collaborations

Azienda Ospedaliera Universitaria Careggi, Florence:   

Psychiatry Team

Pediatric Team

Biochemistry Team

Clinical Biochemistry Team

Pathologists Team

Immunology Team

Endocrinology Team

Genetics Team

 

 

 

Links

http://www.fondazionecareggi.org/progetti/